Análisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratorias

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dc.contributor.advisorAnaya Chavez, Yosed
dc.contributor.authorBoom Aguirre, Valeria Valentina
dc.coverage.spatialBarranquillaspa
dc.creator.emailvaleriav-booma@unilibre.edu.cospa
dc.date.accessioned2025-03-28T21:05:27Z
dc.date.available2025-03-28T21:05:27Z
dc.date.created2025-02-06
dc.description.abstractLas alergias son un grupo de enfermedades muy comunes que impactan las vías respiratorias, la piel, el sistema gastrointestinal o múltiples sistemas al mismo tiempo. En ciertos casos, pueden representar un riesgo mortal para los pacientes, como ocurre con el asma severa y la anafilaxia provocada por picaduras de insectos. Estas condiciones implican un considerable costo para la salud de quienes las padecen, así como un impacto económico y social relevante para sus familias y el sistema de salud. El objetivo de estudio fue analizar el rol del microbioma en el continuo desarrollo de enfermedades alérgicas respiratorias en la población infantil, donde se encontró que, los complejos microbiomas intestinal y respiratorio están implicados de forma central en la ontogenia del sistema inmune, especialmente durante etapas críticas del desarrollo neonatal y la primera infancia. La disbiosis temprana de estas comunidades microbianas endógenas se ha correlacionado consistentemente con un aumento en la susceptibilidad a desarrollar trastornos alérgicos y asma más adelante en la vida. La evidencia actual propone un papel central del microbioma en la patogénesis de las enfermedades alérgicas respiratorias, que podría ser manipulado para desarrollar aproximaciones terapéuticas novedosas para estas condiciones. No obstante, aún faltan estudios definitivos que esclarezcan los mecanismos subyacentes con mayor precisión.spa
dc.description.abstractenglishAllergies are a group of very common diseases that impact the respiratory tract, skin, gastrointestinal system or multiple systems at the same time. In certain cases, they can be life-threatening for patients, as is the case with severe asthma and anaphylaxis caused by insect stings. These conditions imply a considerable cost for the health of those who suffer from them, as well as a relevant economic and social impact for their families and the health system. The aim of the study was to analyze the role of the microbiome in the continuous development of respiratory allergic diseases in the pediatric population, where it was found that the complex intestinal and respiratory microbiome complexes are centrally involved in the ontogeny of the immune system, especially during critical stages of neonatal development and early childhood. Early dysbiosis of these endogenous microbial communities has been consistently correlated with increased susceptibility to develop allergic disorders and asthma later in life. Current evidence proposes a central role of the microbiome in the pathogenesis of respiratory allergic diseases, which could be manipulated to develop novel therapeutic approaches for these conditions. However, definitive studies that elucidate the underlying mechanisms with greater precision are still lacking.spa
dc.description.sponsorshipUniversidad Libre Seccional Barranquilla -- Facultad de Ciencias de la Salud, Exactas y Naturales -- Programa de Microbiologíaspa
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dc.identifier.urihttps://hdl.handle.net/10901/30888
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dc.relation.referencesKemter AM, Nagler CR. Influences on allergic mechanisms through gut, lung, and skin microbiome exposures. Journal of Clinical Investigation. 2019 Apr 1;129(4):1483–92spa
dc.relation.referencesGao Y, Nanan R, Macia L, Tan J, Sominsky L, Quinn TP, et al. The maternal gut microbiome during pregnancy and offspring allergy and asthma. Journal of Allergy and Clinical Immunology. 2021 Sep 1;148(3):669–78spa
dc.relation.referencesValverde-Molina J, García-Marcos L. Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma. Nutrients [Internet]. 2023 Feb 1 [cited 2023 Aug 22];15(3). Available from: https://pubmed.ncbi.nlm.nih.gov/36771193/spa
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dc.relation.referencesVolery M, Scherz V, Jakob W, Bandeira D, Deggim-Messmer V, Lauber-Biason A, et al. Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant 77 microbiome and adverse health outcomes - a prospective cohort study among children born at term. BMJ Open. 2020 Jun 23;10(6):e036275spa
dc.relation.referencesVercelli D. Microbiota and human allergic diseases: the company we keep. Curr Opin Immunol. 2021 Oct 1;72:215–20spa
dc.relation.referencesLosol P, Choi JP, Kim SH, Chang YS. The role of upper airway microbiome in the development of adult asthma. Immune Netw. 2021 Jun 1;21(3)spa
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dc.relation.referencesDennis R, Carabalo L, García E, Caballero A, Aristizabal G, Córdoba H, et al. Asthma and other allergic conditions in Colombia: a study in 6 cities. Ann Allergy Asthma Immunol [Internet]. 2004 [cited 2023 Apr 21];93(6):568–74. Available from: https://pubmed.ncbi.nlm.nih.gov/15609767/spa
dc.relation.referencesDel Campo-Moreno R, Alarcón-Cavero T, D’Auria G, Delgado-Palacio S, Ferrer-Martínez M. Microbiota and Human Health: characterization techniques and transference. Vol. 36, Enfermedades Infecciosas y Microbiologia Clinica. Elsevier Doyma; 2018. p. 241–5.spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/spa
dc.subjectEnfermedades alérgicasspa
dc.subjectAsma infantilspa
dc.subjectRinitis alérgicaspa
dc.subjectMicrobioma humanospa
dc.subjectDisbiosisspa
dc.subjectSistema inmunespa
dc.subjectTracto respiratoriospa
dc.subjectDesarrollo tempranospa
dc.subjectHomeostasis inmunológicaspa
dc.subjectPatogénesis alérgicaspa
dc.subjectComunidades microbianasspa
dc.subjectEpidemiología alérgicaspa
dc.subject.lembMicrobiomasspa
dc.subject.lembAlergia en niñosspa
dc.subject.lembAlergia respiratoriaspa
dc.subject.lembMicrobioma gastrointestinalspa
dc.subject.subjectenglishAllergic diseasesspa
dc.subject.subjectenglishChildhood asthmaspa
dc.subject.subjectenglishAllergic rhinitisspa
dc.subject.subjectenglishHuman microbiomespa
dc.subject.subjectenglishDysbiosisspa
dc.subject.subjectenglishImmune systemspa
dc.subject.subjectenglishRespiratory tractspa
dc.subject.subjectenglishEarly developmentspa
dc.subject.subjectenglishImmune homeostasisspa
dc.subject.subjectenglishAllergic pathogenesisspa
dc.subject.subjectenglishMicrobial communitiesspa
dc.subject.subjectenglishAllergic epidemiologyspa
dc.titleAnálisis del papel del microbioma en el desarrollo de enfermedades alérgicas respiratoriasspa
dc.title.alternativeAnalysis of the role of the microbiome in the development of respiratory allergic diseasesspa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localTesis de Pregradospa

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