Modelo de uso de la planta medicinal Bursera Simaruba y su actividad antiinflamatoria

Vista sencilla de ítem
dc.contributor.advisorParga Lozano, Carlos Hernando
dc.contributor.authorColey Silva, Luis Fernando
dc.contributor.authorAhumada Navarro, Waldy Enrique
dc.coverage.spatialBarranquillaspa
dc.creator.emaillcoley8@gmail.comspa
dc.creator.emailwaldy-odont@hotmail.comspa
dc.date.accessioned2020-01-31T15:41:27Z
dc.date.available2020-01-31T15:41:27Z
dc.date.created2019
dc.description.abstractLa actividad antiinflamatoria ha despertado en los últimos años un gran interés científico en el área farmacológica, principalmente en virtud de la capacidad potencial de ciertos metabolitos de interferir en la evolución de enfermedades que cursan con procesos inflamatorios. Dicho proceso involucra una serie de eventos inespecíficos que pueden ser provocados por numerosos estímulos o agresiones del medio. Debido a esto, un número de plantas medicinales han mostrado actividad farmacológica útil, incluyendo efectos antiinflamatorios. Entre estas plantas, Bursera simaruba, es un árbol comúnmente difundido en Venezuela, Belice, Colombia y Centroamérica. En estos países se ha utilizado con éxito para el tratamiento de infecciones locales y sistémicas. De este modo, se busca describir la respuesta inmunomoduladora de los extractos de la planta Bursera simaruba y su aplicabilidad terapéutica en el tratamiento de enfermedades inflamatorias. Por consiguiente, se realizó una revisión de la literatura científica en diferentes bases de datos (PubMed, Scopus y ScienceDirect) con una ruta de búsqueda sencilla. Se encontró que los metabolitos analizados presentaron efectos inhibitorios sobre la expresión de las citoquinas proinflamatorias, de las enzimas mediadoras y los catabolitos. Esta actividad inhibitoria se debió principalmente a la inactivación de la vía NF-κB o a la regulación de algunos factores de transcripción. En conclusión estos resultados sugieren que la planta Bursera simaruba tiene efectos antiinflamatorios y puede ser una opción potencial en el tratamiento de las enfermedades inflamatorias.spa
dc.description.abstractAnti-inflammatory activity has aroused in recent years a great scientific interest in the pharmacological area, mainly due to the potential capacity of certain metabolites to interfere in the evolution of diseases that occur with inflammatory processes. This process involves a series of nonspecific events that can be caused by numerous stimuli or attacks from the environment. Because of this, a number of medicinal plants have shown useful pharmacological activity, including anti-inflammatory effects. Among these plants, Bursera simaruba, is a tree commonly spread in Venezuela, Belize, Colombia and Central America. In these countries it has been used successfully for the treatment of local and systemic infections. In this way, we seek to describe the immunomodulatory response of the extracts of the Bursera simaruba plant and its therapeutic applicability in the treatment of inflammatory diseases. Therefore, a review of the scientific literature in different databases (PubMed, Scopus and ScienceDirect) was performed with a simple search path. The analyzed metabolites were found to have inhibitory effects on the expression of proinflammatory cytokines, mediating enzymes and catabolites. This inhibitory activity was mainly due to the inactivation of the NF-κB pathway or the regulation of some transcription factors. In conclusion, these results suggest that the Bursera simaruba plant has anti-inflammatory effects and may be a potential option in the treatment of inflammatory diseases.Eng
dc.formatPDFspa
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/10901/17816
dc.language.isospaspa
dc.relation.referencesCarballo M Cortada, C, Gadano, A. Medicinal herbs: Risks and benefits in their uses. Theoria. 2005;14(2):95-108.spa
dc.relation.referencesAmirghofran Z. Medicinal plants as immunosuppressive agents in traditional Iranian medicine. Iran J Immunol. 2010; 3spa
dc.relation.referencesLopez A Hudson, J,B, Towers, G,H,N. Antiviral and antimicrobial activities of Colombian medicinal plants. Journal of Ethnopharmacology. 2001;77(2-3):18996.spa
dc.relation.referencesCracraft J Grifo, F,T. The living planet in crisis: Biodiversity science and policy. 1999;xxiv,-311 p. 5spa
dc.relation.referencesLee A N, Werth, V,P. Activation of autoimmunity following use of immunostimulatory herbal supplements. Archives of Dermatology. 2004;140(6):723-7.spa
dc.relation.referencesGómez Estrada H González Ruiz, A, Noreica, K, Medina, J,D. Actividad antiinflamatoria de productos naturales. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 2011;10(3):182-217.spa
dc.relation.referencesKoeberle A Haberl, E,M, Rossi, A, Pergola, C, Dehm, F, Northoff, H, Troschuetz, R, Sautebin, L, Werz, O. Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E2synthase-1. Bioorganic and Medicinal Chemistry. 2009;17(23):7924-32. 8spa
dc.relation.referencesNicolaides N, Charmandari E, Chrousos G. Overview of Glucocorticoids. Encyclopedia of Endocrine Diseases. 2018;3(Second Edition):64-71.spa
dc.relation.referencesAmann R Peskar, B,A. Anti-inflammatory effects of aspirin and sodium salicylate. European journal of pharmacology. 2002;447(1):1-9.spa
dc.relation.referencesRoth G J, Stanford, N, Majerus, P,W. Acetylation of prostaglandin synthase by aspirin. Proceedings of the National Academy of Sciences of the United States of America. 1975;72(8):3073-6.spa
dc.relation.referencesVane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biology. 1971;231(25):232-5.spa
dc.relation.referencesShukla S Bajpai, V,K, Kim, M. Plants as potential sources of natural immunomodulators. Reviews in Environmental Science and Biotechnology. 2014;13(1):17-33.spa
dc.relation.referencesAmirghofran Z. Herbal medicines for immunosuppression. Iranian Journal of Allergy, Asthma and Immunology. 2012;11(2):111-9.spa
dc.relation.referencesQi Zh. The WHO traditional medicine strategy 2014-2023: Background and progress in the last decade. Global Health History Seminar on Traditional Medicine and Ayurveda. 2015;(March):1-28.spa
dc.relation.referencesSeifert W. Compositions and methods for inhibiting COX-2 expression and treating COX-2 associated disorders by using COX-2 antisense oligonucleotides. US 6344323 B1, 2002. p. 30.spa
dc.relation.referencesRojas M W, Anaya, C, Cano R,J,M, Aristizábal, L,E, Gómez, B,H, Lopera H,L,M. Inmunología de Rojas. 2002. 113–153 p.spa
dc.relation.referencesGuo H Callaway, J,B, Ting, J,P,Y. Inflammasomes: Mechanism of action, role in disease, and therapeutics. Nature Medicine. 2015;21(7):677-87spa
dc.relation.referencesSchroder K Tschopp, J. The inflammasomes. Cell. 2010;140(6):821-32spa
dc.relation.referencesMontaño Estrada LF, Van der Goes TF, Rendón Huerta EP. ¿Qué son los inflamosomas? El NLRP3 como ejemplo. 2016;42-9. 21spa
dc.relation.referencesMilagros García Mesa L Cristina Coma Alfonso, L. Características estructurales y funcionales de las plaquetas. Rev Cubana Angiol y Cir Vasc. 2000;1(2):132-41.spa
dc.relation.referencesAbbas A K, Lichtman, A,H, Pillaj, S. Inmunología celular y molecular. Séptima. 2012. 555 p.spa
dc.relation.referencesLandén N X, Li, D, St\a ahle, M. Transition from inflammation to proliferation: A critical step during wound healing. Cellular and Molecular Life Sciences. 2016;73(20):3861-85.spa
dc.relation.referencesSipe J D. The acute phase response in the pathogenesis of inflammatory disease: Prospects for pharmacotherapy. Clinical Immunotherapeutics. 1999;3(4)spa
dc.relation.referencesLotze M T, Thomson, A,W. Measuring immunity: Basic biology and clinical assessment. 2005. 722 p.spa
dc.relation.referencesChen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget [Internet]. 23 de enero de 2018 [citado 22 de julio de 2019];9(6). Disponible en: http://www.oncotarget.com/fulltext/23208spa
dc.relation.referencesRodríguez F R, Córdoba, G,T. Árboles del Valle Central de Costa Rica: Reproducción. Indio desnudo. Revista Forestal Mesoamericana Kurú. 2011;8(20):39-42.spa
dc.relation.referencesCulioli G Mathe, C, Archier, P, Vieillescazes, C. A lupane triterpene from frankincense (Boswellia sp., Burseraceae). Phytochemistry. 2003;62(4):537-41spa
dc.relation.referencesSyamasundar K V, Mallavarapu, G,R. Two triterpenoid lactones from the resin of Bursera delpechiana. Phytochemistry. 1995;40(1):337-9spa
dc.relation.referencesPeraza-Sánchez S R, Peña-Rodríguez, L,M. Isolation of picropolygamain from the resin of Bursera simaruba. Journal of Natural Products. 1992;55(12):1768-71.spa
dc.relation.referencesPeraza-Sánchez S R, Salazar-Aguilar, N,E, Peña-Rodríguez, L,M. A new triterpene from the resin of Bursera simaruba. Journal of Natural Products. 1995;58(2):271-4.spa
dc.relation.referencesLandis J R, Koch, G,G. The measurement of observer agreement for categorical data. Biometrics. marzo de 1977;33(1):159-74. 42spa
dc.relation.referencesNoguera B Díaz, E, García, M,V, Feliciano, A,S, López-Pérez, J,L, Israel, A. Anti-inflammatory activity of leaf extract and fractions of Bursera simaruba (L.) Sarg (Burseraceae). Journal of Ethnopharmacology. 2004;92(1):129-33spa
dc.relation.referencesAbad M J, Bermejo, P, Carretero, E, Martínez-Acitores, C, Noguera, B, Villar, A. Antiinflammatory activity of some medicinal plant extracts form Venezuela. Journal of ethnopharmacology. 1996;55(1):63-8. 44spa
dc.relation.referencesCarretero ME López-Pérez, JL, Abad, MJ, Bermejo, P, Tillet, S, Israel, A, Noguera-P, B. Preliminary study of the anti-inflammatory activity of hexane extract and fractions from Bursera simaruba (Linneo) Sarg. (Burseraceae) leaves. Journal of Ethnopharmacology. 2008;116(1):11-5spa
dc.relation.referencesBeermann F Orlow, S,J, Lamoreux, M,L. The Tyr (albino) locus of the laboratory mouse. Mammalian genome : official journal of the International Mammalian Genome Society. octubre de 2004;15(10):749-58spa
dc.relation.referencesRice M C, O’Brien, S,J. Genetic variance of laboratory outbred Swiss mice. Nature. enero de 1980;283:157spa
dc.relation.referencesTakamatsu S Tosa, T. Production of L-alanine and D-aspartic acid. Bioprocess technology. 1993;16:25-35.spa
dc.relation.referencesVan De Velde F Lourenço, N,D, Pinheiro, H,M, Bakker, M. Carrageenan: A food-grade and biocompatible support for immobilisation techniques. Advanced Synthesis and Catalysis. 2002;344(8):815-35. 54spa
dc.relation.referencesZacharopoulos V R, Phillips, D,M. Vaginal formulations of carrageenan protect mice from herpes simplex virus infection. Clinical and diagnostic laboratory immunology. julio de 1997;4(4):465-8.spa
dc.relation.referencesBarbeyron T Michel, G, Potin, P, Henrissat, B, Kloareg, B. Iota-carrageenases constitute a novel family of glycoside hydrolases, unrelated to that of kappacarrageenases. The Journal of biological chemistry. noviembre de 2000;275(45):35499-505spa
dc.relation.referencesHenriques M G, Silva, P,M, Martins, M,A, Flores, C,A, Cunha, F,Q, AssreuyFilho, J, Cordeiro, R,S. Mouse paw edema. A new model for inflammation? Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1987;20(2):243-9.spa
dc.relation.referencesPaschapur M S, Patil, M,B, Kumar, R, Patil, S,R. Evaluation of antiinflammatory activity of ethanolic extract of Borassus flabellifer L. male flowers (inflorescences) in experimental animals. Journal of Medicinal Plants Research. 2009;3(2):049-54.spa
dc.relation.referencesSini J M, Yaro, A,H, Ayanwuyi, L,O, Aiyelero, O,M, Mallum, S,M, Gamaniel, K,S. Antinociceptive and anti-inflammatory activities of the aqueous extract of the root bark of Combretum sericeum in rodents. African Journal of Biotechnology. 2010;9(51):8872-6.spa
dc.relation.referencesSugishita E Amagaya, S, Ogihara, Y. Anti-inflammatory testing methods: Comparative evaluation of mice and rats. Journal of pharmacobio-dynamics. agosto de 1981;4(8):565-75.spa
dc.relation.referencesPosadas I Bucci, M, Roviezzo, F, Rossi, A, Parente, L, Sautebin, L, Cirino, G. Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. British journal of pharmacology. mayo de 2004;142(2):331-8.spa
dc.relation.referencesPorto G G, Vasconcelos, B, Cavalcanti Do Egito, S, Valdemiro A, Andrade, E,S,D,S. The use of carrageenan for limiting the mandibular movement in rats: A preliminary experimental study. Medicina Oral, Patologia Oral y Cirugia Bucal. 2010;15(4):653-7spa
dc.relation.referencesRadhakrishnan R Bement, M,K,H, Skyba, D, Sluka, K,A. Models of muscle pain: Carrageenan model and acidic saline model. Pharmacology. 2004;1-28.spa
dc.relation.referencesSalvemini D Wang, Z,Q, Wyatt, P,S, Bourdon, D,M, Marino, M,H, Manning, P,T, Currie, M,G. Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation. British journal of pharmacology. junio de 1996;118(4):829-38.spa
dc.relation.referencesStranden E. A comparison between surface measurements and water displacement volumetry for the quantification of leg edema. Journal of the Oslo city hospitals. diciembre de 1981;31(12):153-5.spa
dc.relation.referencesSatyam S M, Bairy, K,L, Musharraf, S, Fernandes, D,L. Inhibition of croton oilinduced oedema in rat ear skin by topical nicotinamide gel. Pharmacologyonline. 2014;3:22-5spa
dc.relation.referencesGarcia-Romo G S, Caielli, S, Vega, B, Connolly, J, Allantaz, F, Xu, Z, Punaro, M, Baisch, J, Guiducci, C, Coffman, R,L, Barrat, F,J, Banchereau, J, Pascual, V. Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Science translational medicine. marzo de 2011;3(73):73ra20.spa
dc.relation.referencesHakkim A Furnrohr, B,G, Amann, K, Laube, B, Abed, U,A, Brinkmann, V, Herrmann, M, Voll, R,E, Zychlinsky, A. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proceedings of the National Academy of Sciences of the United States of America. mayo de 2010;107(21):9813-8.spa
dc.relation.referencesHuang H Tohme, S, Al-Khafaji, A,B, Tai, S, Loughran, P, Chen, L, Wang, S, Kim, J, Billiar, T, Wang, Y, Tsung, A. Damage-associated molecular patternactivated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology (Baltimore, Md). agosto de 2015;62(2):600-14.spa
dc.relation.referencesLande R Ganguly, D, Facchinetti, V, Frasca, L, Conrad, C, Gregorio, J, Meller, S, Chamilos, G, Sebasigari, R, Riccieri, V, Bassett, R, Amuro, H, Fukuhara, S, Ito, T, Liu, Y,J, Gilliet, M. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Science translational medicine. marzo de 2011;3(73):73ra19.spa
dc.relation.referencesDíaz-Ochoa V E, Jellbauer, S, Klaus, S, Raffatellu, M. Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Frontiers in cellular and infection microbiology. 2014;4:2.spa
dc.relation.referencesSohnle P G, Collins-Lech, C, Wiessner, J,H. The zinc-reversible antimicrobial activity of neutrophil lysates and abscess fluid supernatants. The Journal of infectious diseases. julio de 1991;164(1):137-42. 132spa
dc.relation.referencesDamo S M, Kehl-Fie, T,E, Sugitani, N, Holt, M,E, Rathi, S, Murphy, W,J, Zhang, Y, Betz, Ch, Hench, L, Fritz, G, Skaar, E,P, Chazin, W,J. Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proceedings of the National Academy of Sciences of the United States of America. marzo de 2013;110(10):3841-6spa
dc.relation.referencesHayden J A, Brophy, M,B, Cunden, L,S, Nolan, E,M. High-affinity manganese coordination by human calprotectin is calcium-dependent and requires the histidine-rich site formed at the dimer interface. Journal of the American Chemical Society. enero de 2013;135(2):775-87spa
dc.relation.referencesKehl-Fie T E, Chitayat, S, Hood, M,I, Damo, S, Restrepo, N, García, C, Munro, K,A, Chazin, W,J, Skaar, E,P. Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell host & microbe. agosto de 2011;10(2):158-64spa
dc.relation.referencesRiva M Källberg, E, Björk, P, Hancz, D, Vogl, T, Roth, J, Ivars, F, Leanderson, T. Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent. Immunology. 2012;137(2):172-82.spa
dc.relation.referencesFadok V A, Bratton, D,L, Konowal, A, Freed, P,W, Westcott, J,Y, Henson, P,M. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. The Journal of clinical investigation. febrero de 1998;101(4):890-8.spa
dc.relation.referencesMaderna P Yona, S, Perretti, M, Godson, C. Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26). Journal of immunology (Baltimore, Md : 1950). marzo de 2005;174(6):3727-33.spa
dc.relation.referencesScannell M Flanagan, M,B, DeStefani, A, Wynne, K,J, Cagney, G, Godson, C, Maderna, P. Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages. Journal of immunology (Baltimore, Md : 1950). abril de 2007;178(7):4595-605.spa
dc.relation.referencesKatakami Y Nakao, Y, Koizumi, T, Katakami, N, Ogawa, R, Fujita, T. Regulation of tumour necrosis factor production by mouse peritoneal macrophages: the role of cellular cyclic AMP. Immunology. agosto de 1988;64(4):719-24.spa
dc.relation.referencesChand N Eyre, P. Nonsteroidal anti-inflammatory drugs: A review. New applications in hypersensitivity reactions of cattle and horses. Canadian journal of comparative medicine Revue canadienne de médecine comparée. 1977;41(3):233-40.spa
dc.relation.referencesFerreira S H, Moncada, S, Vane, J,R. Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. British Journal of Pharmacology. febrero de 1997;120(Suppl 1):401-12spa
dc.relation.referencesTauber A I, Kaliner, M, Stechschulte, D,J, Austen, K,F. Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine. Journal of immunology (Baltimore, Md : 1950). julio de 1973;111(1):27-32.spa
dc.relation.referencesJiang Q Lykkesfeldt, J, Shigenaga, M,K, Shigeno, E,T, Christen, S, Ames B N. Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free radical biology & medicine. diciembre de 2002;33(11):1534-42spa
dc.relation.referencesUhlar C M, Whitehead, A,S. Serum amyloid A, the major vertebrate acutephase reactant. Eur J Biochem. 1999;Eng
dc.relation.referencesNewton R F, Roberts, S,M. Prostaglandins and tromboxanes: Butterworths monographs in chemistry. 2016;Eng
dc.relation.referencesHenley JL, Denese, Adrienne A. Immunotherapy of inflammatory sinus and ear disease. 6027712, 2000. p. 10.Eng
dc.relation.referencesAgou F, Chiaravalli J, Yves-Marie C, Francoise B, Alain I, Michel V. Method for screening for selective modulator of the NF-kB pathway activation. 0240040 A1, 2010.Eng
dc.relation.referencesBursera simaruba. Garden & Forest 3. 1890;3(218):73-6.Spa
dc.relation.referencesCorrea Q J, Bernal, H,Y. Especies vegetales promisorias de los países del Convenio Andrés Bello. 1990;Spa
dc.relation.referencesMaldini M Montoro, P, Piacente, S, Pizza, C. Phenolic compounds from Bursera simaruba Sarg. bark: Phytochemical investigation and quantitative analysis by tandem mass spectrometry. Phytochemistry. 2009;70(5):641-9.Eng
dc.relation.referencesFaggioli C E. Bioma. La naturaleza en tus manos. :92.Spa
dc.relation.referencesCiccio J F, Rosales, K,M. Isolation of the lignan yatein from bark of Bursera simaruba (Burseraceae). Ing Cien Quim. 1995Eng
dc.relation.referencesSosa S Balick, M,J, Arvigo, R, Esposito, R,G, Pizza, C, Altinier, G, Tubaro, A. Screening of the topical anti-inflammatory activity of some Central American plants. Journal of Ethnopharmacology. 2002;81(2):211-5.Eng
dc.relation.referencesRiver Ch. CD® ( Sprague Dawley ) IGS Rat. 1997;Spa
dc.relation.referencesBiosciences T. B6 Albino Mouse Models.Eng
dc.relation.referencesCui S Chesson, C, Hope, R. Genetic variation within and between strains of outbred Swiss mice. Laboratory animals. abril de 1993;27(2):116-23Eng
dc.relation.referencesNecas J Bartosikova, L. Carrageenan: A review. Veterinarni Medicina. 2013;58(4):187-205.Eng
dc.relation.referencesTobacman J K. Review of harmful gastrointestinal effects of carrageenan in animal experiments. Environmental Health Perspectives. 2001;109(10):983-94.Eng
dc.relation.referencesPetersson M Wiberg, U, Lundeberg, T, Uvnas-Moberg, K. Oxytocin decreases carrageenan induced inflammation in rats. Peptides. septiembre de 2001;22(9):1479-84.Eng
dc.relation.referencesHandy R L, Moore, P,K. A comparison of the effects of L-NAME, 7-NI and LNIL on carrageenan-induced hindpaw oedema and NOS activity. British journal of pharmacology. marzo de 1998;123(6):1119-26.Eng
dc.relation.referencesOmote K Hazama, K, Kawamata, T, Kawamata, M, Nakayaka, Y, Toriyabe, M, Namiki, A. Peripheral nitric oxide in carrageenan-induced inflammation. Brain research. septiembre de 2001;912(2):171-5.Eng
dc.relation.referencesGuex J J, Perrin, M. Edema and leg volume: Methods of assessment. Angiology. 2000;51(1):9-12.Eng
dc.relation.referencesRabe E Stücker, M, Ottillinger, B. Water displacement leg volumetry in clinical studies-A discussion of error sources. BMC Medical Research Methodology. 2010;10.Eng
dc.relation.referencesSatyam S M, Bairy, K,L, Musharraf, S, Fernandes, D,L. Inhibition of croton oilinduced oedema in rat ear skin by topical nicotinamide gel. Pharmacologyonline. 2014;3:22-5.Eng
dc.relation.referencesGábor M. The mouse ear as a model for cutaneous irritation. Journal of Toxicology - Cutaneous and Ocular Toxicology. 2002;21(3):191-202.Eng
dc.relation.referencesDe Bernardis E Leonardi, G, Caruso, A, Cutili, V,M,C, Amico-Roxas, M. Protective effects of papaverine salicylate in mouse ear dermatitis and PAFinduced rat paw oedema. Agents and Actions. 1994;42(1):29-33.Eng
dc.relation.referencesOtsuka A Kabashima, K. Contribution of basophils to cutaneous immune reactions and Th2-mediated allergic responses. Frontiers in Immunology. 2015;6(August):1-6.Eng
dc.relation.referencesSaeki K Satoh, T, Yokozeki, H. Alpha(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation. The Journal of investigative dermatology. septiembre de 2013;133(9):2161-9.Eng
dc.relation.referencesNakashima Ch Otsuka, A, Kitoh, A, Honda, T, Egawa, G, Nakajima, S, Nakamizo, S, Arita, M, Kubo, M, Miyachi, Y, Kabashima, K. Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis. The Journal of allergy and clinical immunology. julio de 2014;134(1):100-7.Eng
dc.relation.referencesJurupe H Iparraguirre, D, Pérez, I. Estudio de la actividad antiinflamatoria de extractos de Baccharis lanceolata Kunth en animales de laboratorio.Spa
dc.relation.referencesSerhan Ch N, Brain, S,D, Buckley, Ch,D, Gilroy, D,W, Haslett, Ch, O’Neill, L,A,J, Perretti, M, Rossi, A,G, Wallace, J,L. Resolution of inflammation: State of the art, definitions and terms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. febrero de 2007;21(2):325-32.Spa
dc.relation.referencesSugimoto M A, Sousa, L,P, Pinho, V, Perretti, M, Teixeira, M,M. Resolution of inflammation: What controls its onset? Frontiers in immunology. 2016;7:160.Eng
dc.relation.referencesHoffmann A Leung, T,H, Baltimore, D. Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. The EMBO journal. octubre de 2003;22(20):5530-9.Eng
dc.relation.referencesWang V Y,F, Huang, W, Asagiri, M, Spann, N, Hoffmann, A, Glass, Ch, Ghosh, G. The transcriptional specificity of NF-kappaB dimers is coded within the kappaB DNA response elements. Cell reports. octubre de 2012;2(4):824-39.Eng
dc.relation.referencesif functions as an enhancer for nontypeable H. influenzae-induced DEFB4 regulation in epithelial cells. Biochemical and biophysical research communications. enero de 2014;443(3):1035-40.Eng
dc.relation.referencesBohuslav J Kravchenko, V,V, Parry, G,C, Erlich, J,H, Gerondakis, S, Mackman, N, Ulevitch, R,J. Regulation of an essential innate immune response by the p50 subunit of NF-kappaB. The Journal of clinical investigation. noviembre de 1998;102(9):1645-52.Eng
dc.relation.referencesMa X Y, Wang, H, Ding, B, Zhong, H, Ghosh, S, Lengyel, P. The interferoninducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. The Journal of biological chemistry. junio de 2003;278(25):23008-19.Eng
dc.relation.referencesBiswas S K, Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nature immunology. octubre de 2010;11(10):889-96.Eng
dc.relation.referencesAparicio-Soto M Alarcon de la Lastra, C, Cardeno, A, Sánchez-Fidalgo, S, Sánchez-Hidalgo, M. Melatonin modulates microsomal PGE synthase 1 and NFE2-related factor-2-regulated antioxidant enzyme expression in LPS-induced murine peritoneal macrophages. British journal of pharmacology. enero de 2014;171(1):134-44.Eng
dc.relation.referencesLardone P J, Carrillo-Vico, A, Naranjo, M,C, De Felipe, B, Vallejo, A, Karasek, M, Guerrero, J,M. Melatonin synthesized by Jurkat human leukemic T cell line is implicated in IL-2 production. Journal of cellular physiology. enero de 2006;206(1):273-9.Eng
dc.relation.referencesCriollo A Senovilla, L, Authier, H, Maiuri, M,Ch, Morselli, E, Vitale, I, Kepp, O, Tasdemir, E, Galluzzi, L, Shen, Sh, Tailler, M, Delahaye, N, Tesniere, A, De Stefano, D, Younes, A,B, Harper F, Pierron G, Lavandero S, Zitvogel L, Israel A, et al. The IKK complex contributes to the induction of autophagy. The EMBO journal. febrero de 2010;29(3):619-31.Eng
dc.relation.referencesGreten F R, Arkan, M,C, Bollrath, J, Hsu, Li-Ch, Goode, J, Miething, C, Goktuna, S,I, Neuenhahn, M, Fierer, J, Paxian, S, Van Rooijen, N, Xu, Y, O’Cain, T, Jaffee, B,B, Busch, D,H, Duyster J, Schmid RM, Eckmann L, Karin M. NFkappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. septiembre de 2007;130(5):918-31.Eng
dc.relation.referencesBelasco J. mRNA degradation in prokaryotic cells: An overview. En: Control of Messenger RNA Stability. 2012. p. 517.Eng
dc.relation.referencesAnderson P. Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nature reviews Immunology. enero de 2010;10(1):24- 35.Eng
dc.relation.referencesAnderson P. Post-transcriptional control of cytokine production. Nature immunology. abril de 2008;9(4):353-9.Eng
dc.relation.referencesBoldin M P, Baltimore, D. MicroRNAs, new effectors and regulators of NFkappaB. Immunological reviews. marzo de 2012;246(1):205-20.Eng
dc.relation.referencesMa X Becker Buscaglia, L,E, Barker, J,R, Li, Y. MicroRNAs in NF-kappaB signaling. Journal of molecular cell biology. junio de 2011;3(3):159-66.Spa
dc.relation.referencesTaganov K D, Boldin, M,P, Chang, K,J, Baltimore, D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proceedings of the National Academy of Sciences of the United States of America. agosto de 2006;103(33):12481-6.Eng
dc.relation.referencesO’Connell R M, Rao, D,S, Chaudhuri, A,A, Baltimore, D. Physiological and pathological roles for microRNAs in the immune system. Nature reviews Immunology. febrero de 2010;10(2):111-22.Eng
dc.relation.referencesEtzrodt M Cortez-Retamozo, V, Newton, A, Zhao, J, Ng, A, Wildgruber, M, Romero, P, Wurdinger, T, Xavier, R, Geissmann, F, Meylan, E, Nahrendorf, M, Swirski, F,K, Baltimore, D, Weissleder, R, Pittet, M,J. Regulation of monocyte functional heterogeneity by miR-146a and Relb. Cell reports. abril de 2012;1(4):317-24.Eng
dc.relation.referencesVallabhapurapu S Karin, M. Regulation and function of NF-kappaB transcription factors in the immune system. Annual review of immunology. 2009;27:693-733.Eng
dc.relation.referencesBesedovsky H del Rey, A, Sorkin, E, Dinarello, C,A. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science (New York, NY). agosto de 1986;233(4764):652-4.Eng
dc.relation.referencesOrtega-Gómez A Perretti, M, Soehnlein, O. Resolution of inflammation: An integrated view. EMBO molecular medicine. mayo de 2013;5(5):661-74.Eng
dc.relation.referencesVacchini A Locati, M, Borroni, E,M. Overview and potential unifying themes of the atypical chemokine receptor family. Journal of leukocyte biology. junio de 2016;99(6):883-92Eng
dc.relation.referencesDean R A, Cox, J,H, Bellac, C,L, Doucet, A, Starr, A,E, Overall, Ch,M. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: Potential role of the macrophage in terminating polymorphonuclear leukocyte influx. Blood. octubre de 2008;112(8):3455-64.Spa
dc.relation.referencesBamias G Corridoni, D, Pizarro, T, Cominelli, F. New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation. Cytokine. septiembre de 2012;59(3):451-9Eng
dc.relation.referencesOuyang W Rutz, S, Crellin, N,K, Valdez, P,A, Hymowitz, S,G. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annual review of immunology. 2011;29:71-109.Eng
dc.relation.referencesSaraiva M O’Garra, A. The regulation of IL-10 production by immune cells. Nature reviews Immunology. marzo de 2010;10(3):170-81.Eng
dc.relation.referencesSamuelsson B. Role of basic science in the development of new medicines: Examples from the eicosanoid field. The Journal of biological chemistry. marzo de 2012;287(13):10070-80.Eng
dc.relation.referencesMedzhitov R. Inflammation 2010: New adventures of an old flame. Cell. marzo de 2010;140(6):771-6Eng
dc.relation.referencesLevy B D, Clish, C,B, Schmidt, B, Gronert, K, Serhan, C,N. Lipid mediator class switching during acute inflammation: signals in resolution. Nature immunology. julio de 2001;2(7):612-9.Eng
dc.relation.referencesSurh Y J, Na, H,K, Park, J,M, Lee, H,N, Kim, W, Yoon, I,S, Kim, D,D. 15- Deoxy-Delta(1)(2),(1)(4)-prostaglandin J(2), an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling. Biochemical pharmacology. noviembre de 2011;82(10):1335-51.Eng
dc.relation.referencesKim H Seo, J,Y, Kim, K,H. NF-kappaB and cytokines in pancreatic acinar cells. Journal of Korean medical science. agosto de 2000;15 Suppl:S53-4.Eng
dc.relation.referencesShibata T Kondo, M, Osawa, T, Shibata, N, Kobayashi, M, Uchida, K. 15- deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. The Journal of biological chemistry. marzo de 2002;277(12):10459-66.Eng
dc.relation.referencesBandeira-Melo C Serra, M,F, Díaz, B,L, Cordeiro, R,S, Silva, P,M, Lenzi, H,L, Bakhle, Y,S, Serhan, C,N, Martins, M,A. Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: Relationship with concurrent eosinophilia. Journal of immunology (Baltimore, Md : 1950). enero de 2000;164(2):1029-36.Eng
dc.relation.referencesGilroy D W, Colville-Nash, P,R, Willis, D, Chivers, J, Paul-Clark, M,J, Willoughby, D,A. Inducible cyclooxygenase may have anti-inflammatory properties. Nature medicine. junio de 1999;5(6):698-701.Eng
dc.relation.referencesSchwab J M, Chiang, N, Arita, M, Serhan, Ch,N. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. junio de 2007;447(7146):869-74.Eng
dc.relation.referencesFukunaga K Kohli, P, Bonnans, C, Fredenburgh, L,E, Levy, B,D. Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. Journal of immunology (Baltimore, Md : 1950). abril de 2005;174(8):5033-9.Eng
dc.relation.referencesHeadland S E, Norling, L,V. The resolution of inflammation: Principles and challenges. Seminars in immunology. mayo de 2015;27(3):149-60.Eng
dc.relation.referencesGresnigt M S, Joosten, L,A,B, Verschueren, I, van der Meer, J,W,M, Netea, M,G, Dinarello, Ch,A, van de Veerdonk, F,L. Neutrophil-mediated inhibition of proinflammatory cytokine responses. Journal of immunology (Baltimore, Md : 1950). noviembre de 2012;189(10):4806-15.Eng
dc.relation.referencesvan der Meer J H,M, Netea, M,G, Dinarello, C,A. Modulation of muramyl dipeptide stimulation of cytokine production by blood components. Clinical and experimental immunology. junio de 2009;156(3):428-33.Eng
dc.relation.referencesBranzk N Papayannopoulos, V. Molecular mechanisms regulating NETosis in infection and disease. Seminars in immunopathology. julio de 2013;35(4):513- 30.Eng
dc.relation.referencesSchauer Ch Janko, Ch, Munoz, L,E, Zhao, Y, Kienhofer, D, Frey, B, Lell, M, Manger, B, Rech, J, Naschberger, E, Holmdahl, R, Krenn, V, Harrer, T, Jeremic, I, Bilyy, R, Schett, G, Hoffmann, M, Herrmann, M. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nature medicine. mayo de 2014;20(5):511-7.Eng
dc.relation.referencesKahlenberg J M, Carmona-Rivera, C, Smith, C,K, Kaplan, M,J. Neutrophil extracellular trap-associated protein activation of the NLRP3 inflammasome is enhanced in lupus macrophages. Journal of immunology (Baltimore, Md : 1950). febrero de 2013;190(3):1217-26.Eng
dc.relation.referencesGarcia-Romo G S, Caielli, S, Vega, B, Connolly, J, Allantaz, F, Xu, Z, Punaro, M, Baisch, J, Guiducci, C, Coffman, R,L, Barrat, F,J, Banchereau, J, Pascual, V. Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Science translational medicine. marzo de 2011;3(73):73ra20.Eng
dc.relation.referencesHakkim A Furnrohr, B,G, Amann, K, Laube, B, Abed, U,A, Brinkmann, V, Herrmann, M, Voll, R,E, Zychlinsky, A. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proceedings of the National Academy of Sciences of the United States of America. mayo de 2010;107(21):9813-8Eng
dc.relation.referencesHuang H Tohme, S, Al-Khafaji, A,B, Tai, S, Loughran, P, Chen, L, Wang, S, Kim, J, Billiar, T, Wang, Y, Tsung, A. Damage-associated molecular patternactivated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology (Baltimore, Md). agosto de 2015;62(2):600-14.Eng
dc.relation.referencesKnight J S, Kaplan, M,J. Lupus neutrophils: «NET» gain in understanding lupus pathogenesis. Current opinion in rheumatology. septiembre de 2012;24(5):441-50Eng
dc.relation.referencesChamilos, G, Sebasigari, R, Riccieri, V, Bassett, R, Amuro, H, Fukuhara, S, Ito, T, Liu, Y,J, Gilliet, M. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Science translational medicine. marzo de 2011;3(73):73ra19.Eng
dc.relation.referencesPodolska M J, Biermann, M,H,C, Maueröder, Ch, Hahn, J, Herrmann, M. Inflammatory etiopathogenesis of systemic lupus erythematosus: An update. Journal of Inflammation Research. 2015;8:161-71.Eng
dc.relation.referencesCorbin B D, Seeley, E,H, Raab, A, Feldmann, J, Miller, M,R, Torres, V,J, Anderson, K,L, Dattilo, B,M, Dunman, P,M, Gerads, R, Caprioli, R,M, Nacken, W, Chazin, W,J, Skaar EP. Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (New York, NY). febrero de 2008;319(5865):962-5.Eng
dc.relation.referencesDíaz-Ochoa V E, Jellbauer, S, Klaus, S, Raffatellu, M. Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Frontiers in cellular and infection microbiology. 2014;4:2.Eng
dc.relation.referencesHood M I, Skaar, E,P. Nutritional immunity: Transition metals at the pathogenhost interface. Nature reviews Microbiology. julio de 2012;10(8):525-37.Eng
dc.relation.referencesSohnle P G, Collins-Lech, C, Wiessner, J,H. The zinc-reversible antimicrobial activity of neutrophil lysates and abscess fluid supernatants. The Journal of infectious diseases. julio de 1991;164(1):137-42.Eng
dc.relation.referencesBrophy M B, Nakashige, T,G, Gaillard, A, Nolan, E,M. Contributions of the S100A9 C-terminal tail to high-affinity Mn(II) chelation by the host-defense protein human calprotectin. Journal of the American Chemical Society. noviembre de 2013;135(47):17804-17Eng
dc.relation.referencesDamo S M, Kehl-Fie, T,E, Sugitani, N, Holt, M,E, Rathi, S, Murphy, W,J, Zhang, Y, Betz, Ch, Hench, L, Fritz, G, Skaar, E,P, Chazin, W,J. Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proceedings of the National Academy of Sciences of the United States of America. marzo de 2013;110(10):3841-6.Eng
dc.relation.referencesHayden J A, Brophy, M,B, Cunden, L,S, Nolan, E,M. High-affinity manganese coordination by human calprotectin is calcium-dependent and requires the histidine-rich site formed at the dimer interface. Journal of the American Chemical Society. enero de 2013;135(2):775-87.Eng
dc.relation.referencesKehl-Fie T E, Chitayat, S, Hood, M,I, Damo, S, Restrepo, N, García, C, Munro, K,A, Chazin, W,J, Skaar, E,P. Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell host & microbe. agosto de 2011;10(2):158-64.Eng
dc.relation.referencesLoser K Vogl, T, Voskort, M, Lueken, A, Kupas, V, Nacken, W, Klenner, L, Kuhn, A, Foell, D, Sorokin, L, Luger, T,A, Roth, J, Beissert, S. The toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nature medicine. junio de 2010;16(6):713-7.Eng
dc.relation.referencesRiva M Källberg, E, Björk, P, Hancz, D, Vogl, T, Roth, J, Ivars, F, Leanderson, T. Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent. Immunology. 2012;137(2):172-82.Spa
dc.relation.referencesVogl T Tenbrock, K, Ludwig, S, Leukert, N, Ehrhardt, Ch, van Zoelen, M,A,D, Nacken, W, Foell, D, van der Poll, T, Sorg, C, Roth, J. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxininduced shock. Nature medicine. septiembre de 2007;13(9):1042-9.Eng
dc.relation.referencesMedzhitov R. Origin and physiological roles of inflammation. Nature. julio de 2008;454(7203):428-35.Eng
dc.relation.referencesFadok V A, Bratton, D,L, Konowal, A, Freed, P,W, Westcott, J,Y, Henson, P,M. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. The Journal of clinical investigation. febrero de 1998;101(4):890-8.Eng
dc.relation.referencesMaderna P Yona, S, Perretti, M, Godson, C. Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26). Journal of immunology (Baltimore, Md : 1950). marzo de 2005;174(6):3727-33.Eng
dc.relation.referencesScannell M Flanagan, M,B, DeStefani, A, Wynne, K,J, Cagney, G, Godson, C, Maderna, P. Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages. Journal of immunology (Baltimore, Md : 1950). abril de 2007;178(7):4595-605.Eng
dc.relation.referencesLiu Y Cousin, J,M, Hughes, J, Van Damme, J, Seckl, J,R, Haslett, C, Dransfield, I, Savill, J, Rossi, A,G. Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. Journal of immunology (Baltimore, Md : 1950). marzo de 1999;162(6):3639-46.Eng
dc.relation.referencesKatakami Y Nakao, Y, Koizumi, T, Katakami, N, Ogawa, R, Fujita, T. Regulation of tumour necrosis factor production by mouse peritoneal macrophages: the role of cellular cyclic AMP. Immunology. agosto de 1988;64(4):719-24.Eng
dc.relation.referencesChand N Eyre, P. Nonsteroidal anti-inflammatory drugs: A review. New applications in hypersensitivity reactions of cattle and horses. Canadian journal of comparative medicine Revue canadienne de médecine comparée. 1977;41(3):233-40.Eng
dc.relation.referencesNakano J. The prostaglandins. Their effects on 14 clinical conditions. Resident Staff Physician. 1973;93-106.Eng
dc.relation.referencesWilloughby DA Giroud, J,P, Rosa, M,D, Velo, G,P. The control of the inflammatory response with special reference to the prostaglandins. In prostaglandins and cyclic AMP. Biological Actions and Clinical Applications. 1973;187-206.Eng
dc.relation.referencesWilliams T J, Morley, J. Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature. noviembre de 1973;246(5430):215-7.Eng
dc.relation.referencesKaley G Weiner, R. Prostaglandin E-1: A potential mediator of the inflammatory response. Annals of the New York Academy of Sciences. abril de 1971;180:338-50.Eng
dc.relation.referencesFerreira SH, Moncada S, Vane JR. Proceedings: Potentiation by prostaglandins of the nociceptive activity of bradykinin in the dog knee joint. British journal of pharmacology. marzo de 1974;50(3):461P.Eng
dc.relation.referencesFerreira S H, Moncada, S, Vane, J,R. Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs. British Journal of Pharmacology. febrero de 1997;120(Suppl 1):401-12.Eng
dc.relation.referencesFerreira SH, Vane JR. New Aspects of the Mode of Action of Nonsteroid AntiInflammatory Drugs. Annual Review of Pharmacology. abril de 1974;14(1):57- 73.Eng
dc.relation.referencesSondergaard J Greaves, M,W. Prostaglandin E1: Effect on human cutaneous vasculature and skin histamine. The British journal of dermatology. mayo de 1971;84(5):424-8.Eng
dc.relation.referencesTauber A I, Kaliner, M, Stechschulte, D,J, Austen, K,F. Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine. Journal of immunology (Baltimore, Md : 1950). julio de 1973;111(1):27-32.Eng
dc.relation.referencesFord-Hutchinson A W, Smith, M,J, Walker, J,R. Proceedings: Chemotactic activity of solutions of prostaglandin E1. British journal of pharmacology. marzo de 1976;56(3):345P-346P.Eng
dc.relation.referencesHiggs G A, McCall, E, Youlten, L,J. A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis. British journal of pharmacology. abril de 1975;53(4):539-46.Eng
dc.relation.referencesFlower R J. Drugs which inhibit prostaglandin biosynthesis. Pharmacological reviews. marzo de 1974;26(1):33-67.Eng
dc.relation.referencesVane J R, Botting, R,M. Mechanism of action of antiinflammatory drugs. International journal of tissue reactions. 1998;20(1):3-15Eng
dc.relation.referencesEyre P Lewis, A,J. Production of kinins in bovine anaphylactic shock. British journal of pharmacology. febrero de 1972;44(2):311-3.Eng
dc.relation.referencesMiller R L, Melmon, K,L. The related roles of histamine, serotonin and bradykinin in the pathogenesis of inflammation. Series haematologica (1968). 1970;3(1):5-38.Eng
dc.relation.referencesZachariae H S,J, Henningsen, J, Sondergaard, J, Wolf-Jurgensen, P. Plasma kinins in inflammation-relation to other mediators and leukocytes. Scand J clin lab Invest. 1969;24:85-96.Eng
dc.relation.referencesMiller R L, Melmon, K,L. Inflammatory disorders. Clinical Pharmacology. 1972;382-417.Eng
dc.relation.referencesWeissmann G. The role of lysosomes in inflammation and disease. Annual review of medicine. 1967;18:97-112.Eng
dc.relation.referencesChang Y H. Studies on phagocytosis. II. The effect of nonsteroidal antiinflammatory drugs on phagocytosis and on urate crystal-induced canine joint inflammation. The Journal of pharmacology and experimental therapeutics. octubre de 1972;183(1):235-44.Eng
dc.relation.referencesIgnarro L J. Preservation of structural integrity of liver lysosomes and membrane-stabilizing action of anti-inflammatory drugs, catecholamines and cyclic adenosine monophosphate in isotonic salt media. Vol. 22. 1973. 1269– 1282 p.Eng
dc.relation.referencesDi Rosa M Papadimitriou, J,M, Willoughby, D,A. A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs. The Journal of pathology. diciembre de 1971;105(4):239-56.Eng
dc.relation.referencesMcCall E Youlten, L,J,F. Prostaglandin E1 synthesis by phagocytosing rabbit polymorphonuclear leucocytes; its inhibition by indomethacin and its role in chemotaxis. J Physiol. 1973;98-100.Eng
dc.relation.referencesBerry P A, Collier, H,O. Bronchoconstrictor action and antagonism of a slowreacting substance from anaphylaxis of guinea-pig isolated lung. British journal of pharmacology and chemotherapy. agosto de 1964;23:201-16Eng
dc.relation.referencesCollier O J, Sweatman, W,J,F. Antagonism by fenamates of prostaglandin F2a and of slow reacting substance on human bronchial muscle. Vol. 219. 1968. 864–865 pEng
dc.relation.referencesBluestone R. Rheumatoid Arthritis: Medical management. British Medical Journal. 1970;4(5735):602-4Eng
dc.relation.referencesHarrigan M R, Tuteja, S, Neudeck, B,L. Indomethacin in the management of elevated intracranial pressure: A review. Journal of neurotrauma. septiembre de 1997;14(9):637-50.Eng
dc.relation.referencesRasmussen M. Treatment of elevated intracranial pressure with indomethacin: Friend or foe? Acta anaesthesiologica Scandinavica. marzo de 2005;49(3):341-50.Eng
dc.relation.referencesRoberts R G, Redman, J,W. Indomethacin: A review of its role in the management of traumatic brain injury. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine. diciembre de 2002;4(4):271-80Eng
dc.relation.referencesSlavik R S, Rhoney, D,H. Indomethacin: A review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients. Neurological research. julio de 1999;21(5):491-9.Eng
dc.relation.referencesJihyeung J Picinich, S,C, Yang, Zh, Zhao, Y, Suh, N, Kong, A,N, Yang, Ch. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis. 2009;31(4):533-42.Eng
dc.relation.referencesTraber M G. Vitamin E. Bowman BA and R RM, editor. Washington, DC.: ILSI Press; 2006. 211–219 p.Spa
dc.relation.referencesCook-Mills J M, McCary Ch A. Isoforms of vitamin E differentially regulate inflammation. Endocrine, metabolic & immune disorders drug targets. 2010;10:348-66.Eng
dc.relation.referencesFord E S, Schleicher, R,L, Mokdad, A,H, Ajani, U,A, Liu, S. Distribution of serum concentrations of alpha-tocopherol and gamma-tocopherol in the US population. The American journal of clinical nutrition. 2006;84(2):375-83.Eng
dc.relation.referencesBauernfeind J B. Tocopherols in food. Vitamin E: A comprehensive treatise. New York and Basel Ed, editor. 1980. 99–167 p.Eng
dc.relation.referencesHunter S C, Cahoon, E,B. Enhancing vitamin E in oilseeds: unraveling tocopherol and tocotrienol biosynthesis. Lipids. marzo de 2007;42(2):97-108.Spa
dc.relation.referencesSchneider C. Chemistry and biology of vitamin E. Molecular nutrition & food research. enero de 2005;49(1):7-30.Eng
dc.relation.referencesMunteanu A Zingg, J,M, Azzi, A. Anti-atherosclerotic effects of vitamin E? Myth or reality? Journal of Cellular and Molecular Medicine. 2004;8(1):59-76.Eng
dc.relation.referencesMorley S Cecchini, M, Zhang, W, Virgulti, A, Noy, N, Atkinson, J, Manor, D. Mechanisms of ligand transfer by the hepatic tocopherol transfer protein. The Journal of biological chemistry. junio de 2008;283(26):17797-804.Eng
dc.relation.referencesQian J Morley, S, Wilson, K, Nava, P, Atkinson, J, Manor, D. Intracellular trafficking of vitamin E in hepatocytes: The role of tocopherol transfer protein. Journal of lipid research. octubre de 2005;46(10):2072-82.Eng
dc.relation.referencesTraber M G. Vitamin E regulatory mechanisms. Annual review of nutrition. 2007;27:347-62.Eng
dc.relation.referencesSontag T J, Parker, R,S. Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. The Journal of biological chemistry. julio de 2002;277(28):25290-6.Eng
dc.relation.referencesSontag T J, Parker, R,S. Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase. Journal of lipid research. mayo de 2007;48(5):1090-8.Eng
dc.relation.referencesChiku S Hamamura, K, Nakamura, T. Novel urinary metabolite of d-deltatocopherol in rats. Journal of lipid research. 1984;25(1):40-8.Eng
dc.relation.referencesSwanson J E, Ben, R,N, Burton, G,W, Parker, R,S. Urinary excretion of 2,7, 8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman is a major route of elimination of gamma-tocopherol in humans. Journal of lipid research. abril de 1999;40(4):665-71Eng
dc.relation.referencesParker R S, Swanson, J,E. A novel 5’-carboxychroman metabolite of γtocopherol secreted by HepG2 cells and excreted in human urine. Biochemical and Biophysical Research Communications. 2000;269(2):580-3.Eng
dc.relation.referencesSimon E J, Gross, C,S, Milhorat, A,T. The metabolism of vitamin E. I. The absorption and excretion of d-alpha-tocopheryl-5-methyl-C14-succinate. The Journal of biological chemistry. agosto de 1956;221(2):797-805.Eng
dc.relation.referencesSimon E. J. The metabolism of vitamin E. II. Purification and characterization of urinary metabolites of alpha-tocopherol. The Journal of biological chemistry. agosto de 1956;221(2):807-17.Eng
dc.relation.referencesStocker R. The ambivalence of vitamin E in atherogenesis. Trends in biochemical sciences. junio de 1999;24(6):219-23.Eng
dc.relation.referencesCachia O Leger, C,L, Descomps, B. Monocyte superoxide production is inversely related to normal content of alpha-tocopherol in low-density lipoprotein. Atherosclerosis. junio de 1998;138(2):263-9.Eng
dc.relation.referencesStocker R. The ambivalence of vitamin E in atherogenesis. Trends in biochemical sciences. junio de 1999;24(6):219–223.Eng
dc.relation.referencesKeaney J F,Jr. Atherosclerosis: From lesion formation to plaque activation and endothelial dysfunction. Molecular aspects of medicine. 2000;21(4-5):99- 166Eng
dc.relation.referencesSerbinova E Kagan, V, Han, D, Packer, L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free radical biology & medicine. 1991;10(5):263-75.Eng
dc.relation.referencesSuzuki Y J, Packer, L. Inhibition of NF-kappa B activation by vitamin E derivatives. Biochemical and biophysical research communications. mayo de 1993;193(1):277-83.Eng
dc.relation.referencesCooney R V, Harwood, P,J, Franke, A,A, Narala, K, Sundstrom, A,K, Berggren, P,O, Mordan, L,J. Products of gamma-tocopherol reaction with NO2 and their formation in rat insulinoma (RINm5F) cells. Free radical biology & medicine. septiembre de 1995;19(3):259-69.Eng
dc.relation.referencesCooney RV, Franke AA, Harwood PJ, Hatch-Pigott V, Custer LJ, Mordan LJ. Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alphatocopherol. Proceedings of the National Academy of Sciences. 1993;90(5):1771- 5.Eng
dc.relation.referencesHoglen N C, Waller, S,C, Sipes, I,G, Liebler, D,C. Reactions of peroxynitrite with gamma-tocopherol. Chemical research in toxicology. abril de 1997;10(4):401-7.Eng
dc.relation.referencesJiang Q Lykkesfeldt, J, Shigenaga, M,K, Shigeno, E,T, Christen, S, Ames B N. Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free radical biology & medicine. diciembre de 2002;33(11):1534-42.Eng
dc.relation.referencesGoss S P, Hogg, N, Kalyanaraman, B. The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite. Archives of biochemistry and biophysics. marzo de 1999;363(2):333-40.Eng
dc.relation.referencesReiter E Jiang, Q, Christen, S. Anti-inflammatory properties of α- and γtocopherol. Nano. 2007;6(9):2166-71.Eng
dc.relation.referencesBoscoboinik D Szewczyk, A, Hensey, C, Azzi, A. Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. The Journal of biological chemistry. abril de 1991;266(10):6188-94.Eng
dc.relation.referencesTasinato A Boscoboinik, D, Bartoli, G,M, Maroni, P, Azzi, A. d-alphatocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proceedings of the National Academy of Sciences of the United States of America. diciembre de 1995;92(26):12190-4.Eng
dc.relation.referencesRicciarelli R Tasinato, A, Clément, S, Ozer, N,K, Boscoboinik, D, Azzi, A. Alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state. Biochemical Journal. agosto de 1998;334(Pt 1):243-9.Eng
dc.relation.referencesWu D Liu, L, Meydani, M, Meydani, S,N. Vitamin E increases production of vasodilator prostanoids in human aortic endothelial cells through opposing effects on cyclooxygenase-2 and phospholipase A2. The Journal of nutrition. agosto de 2005;135(8):1847-53.Eng
dc.relation.referencesFreedman J E, Farhat, J,H, Loscalzo, J, Keaney, J,F,Jr. Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation. noviembre de 1996;94(10):2434-40.Eng
dc.relation.referencesKempna P Reiter, E, Arock, M, Azzi, A, Zingg, J,M. Inhibition of HMC-1 mast cell proliferation by vitamin E: Involvement of the protein kinase B pathway. The Journal of biological chemistry. diciembre de 2004;279(49):50700-9.Eng
dc.relation.referencesSury M D, Frese-Schaper, M, Muhlemann, M,K, Schulthess, F,T, Blasig, I,E, Tauber, M,G, Shaw, S,G, Christen, S. Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase. Free radical biology & medicine. noviembre de 2006;41(9):1372-83.Eng
dc.relation.referencesSugiyama S Kugiyama, K, Ogata, N, Doi, H, Ota, Y, Ohgushi, M, Matsumura, T, Oka, H, Yasue, H. Biphasic regulation of transcription factor nuclear factorkappaB activity in human endothelial cells by lysophosphatidylcholine through protein kinase C-mediated pathway. Arteriosclerosis, thrombosis, and vascular biology. abril de 1998;18(4):568-76Eng
dc.relation.referencesDevaraj S Jialal, I. Alpha-tocopherol decreases interleukin-1 beta release from activated human monocytes by inhibition of 5-lipoxygenase. Arteriosclerosis, thrombosis, and vascular biology. abril de 1999;19(4):1125-33.Eng
dc.relation.referencesJiang Q Elson-Schwab, I, Courtemanche, C, Ames, B,N. Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. octubre de 2000;97(21):11494-9Eng
dc.relation.referencesChristen S Woodall, A,A, Shigenaga, M,K, Southwell-Keely, P,T, Duncan, M,W, Ames, B,N. Gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: Physiological implications. Proceedings of the National Academy of Sciences of the United States of America. abril de 1997;94(7):3217-22Eng
dc.relation.referencesO’Leary K A, de Pascual-Teresa, S, Needs, P,W, Bao, Y,P, O’Brien, N,M, Williamson, G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutation research. julio de 2004;551(1-2):245-54.Eng
dc.relation.referencesChan A C, Tran, K, Pyke, D,D, Powell, W,S. Effects of dietary vitamin E on the biosynthesis of 5-lipoxygenase products by rat polymorphonuclear leukocytes (PMNL). Biochimica et biophysica acta. octubre de 1989;1005(3):265-9.Eng
dc.relation.referencesJiang Q Ames, B,N. Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. mayo de 2003;17(8):816-22.Eng
dc.relation.referencesNabil Mohamed B Nicolau-Darimont, Ch, Jalil, B. Peltatin for the treatment of chronic inflammatory disorders. [Internet]. Vol. 002. 2015. 354 p. Disponible en: http://appft1.uspto.gov/netacgi/nphParser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnu m.html&r=1&f=G&l=50&s1=20150057344.PGNR.&OS=DN/20150057344&RS= DN/20150057344Spa
dc.relation.referencesSalvador Morán E. Papel del receptor nuclear PPARgamma en la inflamación y la esteatosis hepática [PhD Thesis]. 2013.Spa
dc.relation.referencesLintas C Balduzzi, A,M, Bernardini, M,P, Di Muccio, A. Distribution of hydrocarbons in bovine tissues. Lipids. marzo de 1979;14(3):298-303.Spa
dc.relation.referencesSeong Y A, Hwang, D, Kim, G,D. The anti-inflammatory effect of gnaphalium affine through inhibition of NF-κB and MAPK in lipopolysaccharide-stimulated RAW264.7 cells and analysis of its phytochemical components. Cell Biochemistry and Biophysics. 2016;74(3):407-17.Eng
dc.relation.referencesBrownlie R P, Brownrigg, N,J, Butcher, H,M, Garcia, R, Jessup, R, Lee, V,J, Tunstall, S, Wayne, M,G. ZD1542, a potent thromboxane A2 synthase inhibitor and receptor antagonist in vitro. British Journal of Pharmacology. diciembre de 1993;110(4):1600-6.Eng
dc.relation.referencesFiddler G I, Lumley, P. Preliminary clinical studies with thromboxane synthase inhibitors and thromboxane receptor blockers. A review. Circulation. enero de 1990;81(1 Suppl):I69-78; discussion I79–80.Eng
dc.relation.referencesLee T H, Jung, M, Bang, M,H, Chung, D,K, Kim, J. Inhibitory effects of a spinasterol glycoside on lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines via down-regulating MAP kinase pathways and NF-κB activation in RAW264.7 macrophage cells. International Immunopharmacology. 2012;13(3):264-70Spa
dc.relation.referencesde Beaux A C, Ross, J,A, Maingay, J,P, Fearon, K,C, Carter, D,C. Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis. The British journal of surgery. agosto de 1996;83(8):1071-5.Eng
dc.relation.referencesGukovskaya A S, Gukovsky, I, Zaninovic, V, Song, M, Sandoval, D, Gukovsky, S, Pandol, S,J. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. The Journal of clinical investigation. octubre de 1997;100(7):1853-62.Eng
dc.relation.referencesNorman J G, Fink, G,W, Denham, W, Yang, J, Carter, G, Sexton, C, Falkner, J, Gower, W,R, Franz, M,G. Tissue-specific cytokine production during experimental acute pancreatitis. A probable mechanism for distant organ dysfunction. Digestive diseases and sciences. agosto de 1997;42(8):1783-8.Eng
dc.relation.referencesRakonczay Z Jr, Hegyi, P, Takacs, T, McCarroll, J, Saluja, A,K. The role of NF-kappaB activation in the pathogenesis of acute pancreatitis. Gut. febrero de 2008;57(2):259-67.Eng
dc.relation.referencesAlakurtti S Mäkelä, T, Koskimies, S, Yli-Kauhaluoma, J. Pharmacological properties of the ubiquitous natural product betulin. European Journal of Pharmaceutical Sciences. 2006;29(1):1-13.Eng
dc.relation.referencesHuguet A del Carmen Recio, M, Manez, S, Giner, R, Rios, J. Effect of triterpenoids on the inflammation induced by protein kinase C activators, neuronally acting irritants and other agents. European journal of pharmacology. diciembre de 2000;410(1):69-81.Eng
dc.relation.referencesBernard P Scior, T, Didier, B, Hibert, M, Berthon, J,Y. Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors. Phytochemistry. noviembre de 2001;58(6):865-74.Eng
dc.relation.referencesFlekhter O B, Boreko, E,I, Nigmatullina, L,R, Tret´yakova, E,V, Pavlova, N,I, Baltina, L,A, Nikolaeva, S,N, Savinova, O,V, Galin, F,Z, Tolstikov, G,A. Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives. Bioorganicheskaia khimiia. 2003;29(6):655-61.Eng
dc.relation.referencesYing-Chih. L Hao-Yuan, Ch, Tai-Hung, H, Hsin-Wei, H, Yi-Hsuan, L, WenHuang, P. Analgesic and anti-inflammatory activities of Torenia concolor Lindley var. formosana Yamazaki and betulin in mice. The American journal of Chinese medicine. 2009;37(1):97-111.Eng
dc.relation.referencesPandey Bh K, Rizvi, I,S. Markers of oxidative stress in erythrocytes during aging in humans. Ann N Y Acad Sci. 2007;1100(1):373-82.Eng
dc.relation.referencesFernández M A, de las Heras, B, García, M,D, Saenz, M,T, Villar, A. New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. The Journal of pharmacy and pharmacology. noviembre de 2001;53(11):1533- 9.Eng
dc.relation.referencesGeetha T Varalakshmi, P, Latha, R,M. Effect of triterpenes from Crataeva nurvala stem bark on lipid peroxidation in adjuvant induced arthritis in rats. Pharmacological research. marzo de 1998;37(3):191-5.Eng
dc.relation.referencesBani S Kaul, A, Khan, B, Ahmad, Sh,F, Suri, K,A, Gupta, B,D, Satti, N,K, Qazi, G,N. Suppression of T lymphocyte activity by lupeol isolated from Crataeva religiosa. Phytotherapy research : PTR. abril de 2006;20(4):279-87.Spa
dc.relation.referencesVasconcelos J F, Teixeira, M,M, Barbosa-Filho, J,M, Lucio, A,S,S,C, Almeida, J,R,G,S, de Queiroz, L,P, Ribeiro-Dos-Santos, R, Soares, M,B,P. The triterpenoid lupeol attenuates allergic airway inflammation in a murine model. International immunopharmacology. septiembre de 2008;8(9):1216-21.Eng
dc.relation.referencesYamashita K Lu, H, Lu, J, Chen, G, Yokoyama, T, Sagara, Y, Manabe, M, Kodama, H. Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils. Clinica chimica acta; international journal of clinical chemistry. noviembre de 2002;325(1-2):91-6.Eng
dc.relation.referencesLee S H, Son, M,J, Ju, H,K, Lin, Ch,X, Moon, T,Ch, Choi, HG, Son, J,K, Chang, H,W. Dual inhibition of cyclooxygenases-2 and 5-lipoxygenase by deoxypodophyllotoxin in mouse bone marrow-derived mast cells. Biological & pharmaceutical bulletin. junio de 2004;27(6):786-8.Eng
dc.relation.referencesJin M Moon, T,Ch, Quan, Zh, Lee, E, Kim, Y,K, Yang, J,H, Suh, SJ, Jeong, T,Ch, Lee, S,H, Kim, Ch-H, Chang, H,W. The naturally occurring flavolignan, deoxypodophyllotoxin, inhibits lipopolysaccharide-induced iNOS expression through the NF-kappaB activation in RAW264.7 macrophage cells. Biological & pharmaceutical bulletin. julio de 2008;31(7):1312-5.Eng
dc.relation.referencesKhaled M Jiang, Zh,Zh, Zhang, L,Y. Deoxypodophyllotoxin: A promising therapeutic agent from herbal medicine. Journal of Ethnopharmacology. 2013;149(1):24-34Eng
dc.relation.referencesQuintans-Júnior L J, Souza, T,T, Leite, B,S, Lessa, N,M,N, Bonjardim, L,R, Santos, M,R,V, Alves, P,B, Blank, A,F, Antoniolli, A,R. Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents. Phytomedicine : international journal of phytotherapy and phytopharmacology. agosto de 2008;15(8):619-24.Eng
dc.relation.referencesMelo M S, Sena, L,C,S, Barreto, F,J,N, Bonjardim, L,R, Almeida, J,R,G,S, Lima, J,T, De Sousa, D,P, Quintans-Júnior, L,J. Antinociceptive effect of citronellal in mice. Pharmaceutical biology. abril de 2010;48(4):411-6.Eng
dc.relation.referencesQuintans-Júnior L J, Oliveira, M,G,B, Santana, M,F, Santana, M,T, Guimaraes, A,G, Siqueira, J,S, De Sousa, D,P, Almeida, R,N. alpha-Terpineol reduces nociceptive behavior in mice. Pharmaceutical biology. junio de 2011;49(6):583-6.Eng
dc.relation.referencesHassan S B, Gali-Muhtasib, H, Goransson, H, Larsson, R. Alpha terpineol: A potential anticancer agent which acts through suppressing NF-kappaB signalling. Anticancer research. junio de 2010;30(6):1911-9.Eng
dc.relation.referencesYang E-J Yim, EY, Song, G, Kim, G,O, Hyun, Ch-G. Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts. Interdisciplinary toxicology. diciembre de 2009;2(4):245-9.Spa
dc.relation.referencesPino J A, Marbot, R, Fuentes, V. Characterization of volatiles in bullock’s heart (Annona reticulata L.) fruit cultivars from Cuba. Journal of agricultural and food chemistry. junio de 2003;51(13):3836-9.Eng
dc.relation.referencesBrand C Townley, S,L, Finlay-Jones, J,J, Hart, P,H. Tea tree oil reduces histamine-induced oedema in murine ears. Inflammation research : official journal of the European Histamine Research Society . [et al]. junio de 2002;51(6):283-9Eng
dc.relation.referencesPeana A T, Moretti, M,D,L. Pharmacological activities and applications of Salvia sclarea and Salvia desoleana essential oils. Studies in Natural Products Chemistry. 2002;26(PART G):391-423.Eng
dc.relation.referencesPeana A T, Aquila, P,S,D, Panin, F, Serra, G, Pippia, P, Moretti, M,D,L. Antiinflammatory activity of linalool and linalyl acetate constituents of essential oils. 2002;721-6.Eng
dc.relation.referencesElisabetsky E Brum, L,F, Souza, D,O. Anticonvulsant properties of linalool in glutamate-related seizure models. Phytomedicine : international journal of phytotherapy and phytopharmacology. mayo de 1999;6(2):107-13.Eng
dc.relation.referencesHuo M Cui, X, Xue, J, Chi, G, Gao, R, Deng, X, Guan, Sh, Wei, J, Soromou, L,W, Feng, H, Wang, D. Anti-inflammatory effects of linalool in RAW 264.7 macrophages and lipopolysaccharide-induced lung injury model. Journal of Surgical Research. 2013;180(1):e47-54.Eng
dc.relation.referencesHartsel J A, Eades, J, Hickory, B, Makriyannis, A. Cannabis sativa and Hemp. [Internet]. Elsevier Inc.; 2016. 735–754 p. Disponible en: http://dx.doi.org/10.1016/B978-0-12-802147-7.00053-XEng
dc.relation.referencesYu L Yan, J, Sun, Zh. D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways. Molecular Medicine Reports. 2017;15(4):2339-46.Eng
dc.relation.referencesChowdhury N U, Farooq, T, Abdullah, S, Mahadi, A,S,Hasan,M, Paran, T,Z, Hasan, N, Mohib, M, Sagor, A,T,Alam,A. Matrix Metalloproteinases (MMP), a major responsible downstream signaling molecule for cellular damage - A review. 2016;(2005):7-8.Eng
dc.relation.referencesKoeberle A, Werz O. Natural products as inhibitors of prostaglandin E2and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis. Biotechnology Advances. 2018;36(6):1709-23.Eng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subjectPlantas medicinalesspa
dc.subjectTratamiento de enfermedadesspa
dc.subjectMetabolitosspa
dc.subject.lembBiotecnología vegetalspa
dc.subject.lembPlantas medicinales -- Investigacionesspa
dc.subject.lembAgentes antiinflamatoriosspa
dc.subject.lembBursera simaruba -- Biotecnologíaspa
dc.subject.proposalBurseraspa
dc.subject.proposalCitoquinasspa
dc.subject.proposalAntiinflamatoriosspa
dc.subject.proposalPlantas medicinalesspa
dc.subject.proposalMediadores de inflamaciónspa
dc.subject.proposalInmunomodulaciónspa
dc.subject.subjectenglishBurseraspa
dc.subject.subjectenglishAnti-inflammatoryspa
dc.subject.subjectenglishCytokinesspa
dc.subject.subjectenglishMedicinal plantsspa
dc.subject.subjectenglishInflammation mediatorsspa
dc.subject.subjectenglishImmunomodulationspa
dc.titleModelo de uso de la planta medicinal Bursera Simaruba y su actividad antiinflamatoriaspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localTesis de Maestríaspa

Archivos

Bloque original

Mostrando 1 - 1 de 1
Miniatura
Nombre:
1129568542.pdf
Tamaño:
2.5 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar

Bloque de licencias

Mostrando 1 - 1 de 1
Miniatura
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar

Colecciones

Maestría en Biotecnología