Alprazolam A Therapeutic Alternative in Hypertensive Urgency

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dc.contributor.authorRodríguez Arbeláez, Oswaldo
dc.contributor.authorRey Puente, Joanny
dc.contributor.authorRojano Rada, Jairo
dc.date2019-11-29
dc.descriptionObjective: To compare the combination therapy of captopril plus alprazolam versus captopril plus placebo in the management of hypertensive emergency (UH). Method: It is a clinical trial, uncentric, double blind, semi-randomized, in ages between 45 and 80 years with UH that met the criteria of JNC VII, attended in the emergency service between August 2017 - February 2018, distributed in group A (Control, n = 41) and group B (experimental, n = 55) who received captopril plus placebo and alprazolam and captopril respectively. Results: There was a predominance of the female gender in both groups, and also the degree of mild anxiety was the most frequent. In the experimental group there was a significant decrease at 30, 60 and 90 minutes of the MAP of -19%, -24 and -27% with a P 0.0000, in PAS at 30 minutes it was -17%, 60 minutes of -22% and 90 minutes -26%, and in the PAD in the aforementioned time intervals it was -21%, -26% and -28%. With a reduction equal to or greater than 25% of the average blood pressure in group B, after 90 min of treatment. According to the RR those who received the experimental treatment were about 7.5 times more likely to lower blood pressure effectively at 90 min, the NNT indicates that it is necessary to treat only 2 patients for one to benefit. Conclusion: According to these results we can discern that the use of alprazolam can be a therapeutic alternative in the hypertensive emergency.en-US
dc.descriptionObjetivo: Comparar la terapia combinada de captopril mas alprazolam versus captopril mas placebo en el manejo de urgencia hipertensiva (UH). Método: Es un ensayo clínico, uncéntrico, doble ciego, semialeatorizado, en edades comprendidas entre 45 y 80 años con UH que cumplían los criterios del JNC VII, atendidos en el servicio de emergencia entre Agosto 2017 – Febrero del 2018, distribuidos en grupo A (Control, n=41) y grupo B (experimental, n= 55) los cuales recibieron captopril mas placebo y alprazolam y captopril respectivamente. Resultados: Hubo predominio del género femenino en ambos grupos, y también el grado de ansiedad leve fue la más frecuente. En el grupo experimental hubo un descenso significativo a los 30, 60 y 90 minutos de la PAM de - 19%, -24 y -27% con una P 0.0000, en PAS  a los 30 minutos era de  -17%, 60 minutos de -22% y 90 minutos -26%, y en la PAD en los intervalos de tiempo antes citado  fue -21%,  -26% y  -28%. Con una reducción igual o mayor a 25% de la presión arterial media en el grupo B, luego de 90 min de tratamiento. Según el RR aquellos que recibieron el tratamiento experimental tuvieron cerca de 7,5 veces más probabilidades de disminuir la presión arterial de forma efectiva a los 90 min, el NNT indica que es necesario tratar únicamente a 2 pacientes para que uno se beneficie. Conclusión: Acorde con estos resultados podemos discernir que el uso del alprazolam puede ser una alternativa terapéutica en la urgencia hipertensiva.es-ES
dc.formatapplication/pdf
dc.identifierhttps://revistas.unilibre.edu.co/index.php/biociencias/article/view/6021
dc.identifier10.18041/2390-0512/biociencias.2.6021
dc.identifier.urihttp://hdl.handle.net/10901/18382
dc.languagespa
dc.language.isospaspa
dc.publisherUniversidad Librees-ES
dc.relationhttps://revistas.unilibre.edu.co/index.php/biociencias/article/view/6021/5545
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dc.relation.ispartofjournalRevistas - Ciencias de la Saludspa
dc.rightsDerechos de autor 2019 Biocienciases-ES
dc.rightshttps://creativecommons.org/licenses/by-sa/4.0/deed.eses-ES
dc.rights.licenseAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.sourceBiociencias; Vol 14 No 2 (2019): Biociencias; 67-80en-US
dc.sourceBiociencias; Vol. 14 Núm. 2 (2019): Biociencias; 67-80es-ES
dc.source2390-0512
dc.source0124-0110
dc.subjectAnsiedadspa
dc.subjectUrgencia hipertensivaspa
dc.subjectTerapiaspa
dc.subject.proposalUrgencia hipertensivaes-ES
dc.subject.proposalalprazolames-ES
dc.subject.proposalcaptopriles-ES
dc.subject.proposalAnsiedades-ES
dc.titleAlprazolam A Therapeutic Alternative in Hypertensive Urgencyen-US
dc.titleAlprazolam Una Alternativa Terapéutica en Urgencia Hipertensivaes-ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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