Evaluación de la actividad antimicrobiana de nanopartículas de Hierro (FeNPs) sintetizadas con el extracto de Annona Muricata L. controladas mediante micela inversa

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dc.contributor.advisorRodríguez Macias, Juan David
dc.contributor.advisorMéndez López, Maximiliano Ernesto
dc.contributor.authorMuñoz Fontalvo, Luis Alberto
dc.coverage.spatialBarranquillaspa
dc.creator.emailluis-munozf@unilibre.edu.cospa
dc.date.accessioned2023-08-08T20:29:02Z
dc.date.available2023-08-08T20:29:02Z
dc.date.created2023-06-10
dc.description.abstractLa nanotecnología ha venido consolidándose como una tecnología clave para una amplia gama de aplicaciones siendo una herramienta prometedora tanto en diagnóstico y terapéutica, dadas sus funciones inherentes a nanoescala sobre los componentes biológicos de las células. En la presente investigación se informa sobre la síntesis de nanopartículas de Hierro (FeNPs) usando extracto de Annona Muricata L. controladas mediante micela inversa y su eficacia antimicrobiana frente a bacterias de interés clínico. Las FeNPs biosintetizadas posiblemente esféricas, discretas y estabilizadas por entidades fitoquímicas se caracterizaron mediante espectroscopía ultravioleta visible, dispersión de la luz dinámica, espectroscopia infrarroja por transformada de Fourier. los resultados de DLS para tamaño hidrodinámico de partícula promedio es de 27.98 nm con un RSD de 4.2% usando extracto al 20 % en la síntesis controlada por micela inversa. El resultado de evaluación antimicrobiana mostró que las nanopartículas de hierro sintetizadas, a los diferentes tratamientos no presentaron halos de inhibición indiscutibles, por tanto, no tuvieron actividad antibacteriana frente a p. aeruginosa, s. aureus, enterococcus y e. colispa
dc.description.abstractenglishNanotechnology has been established as a key technology for a wide range of applications, being a promising tool in both diagnosis and therapeutics due to its inherent nano-scale functions on the biological components of cells. This research reports on the synthesis of Iron nanoparticles (FeNPs) using Annona Muricata L. extract controlled by reverse micelle and their antimicrobial efficacy against clinically relevant bacteria. The biosynthesized FeNPs, possibly spherical, discrete, and stabilized by phytochemical entities, were characterized using UV-visible spectroscopy, dynamic light scattering, and Fourier-transform infrared spectroscopy. The DLS results for the average hydrodynamic particle size were 27.98 nm with an RSD of 4.2%, using a 20% extract in the reverse micelle-controlled synthesis. The antimicrobial evaluation showed that the synthesized iron nanoparticles, under different treatments, did not exhibit clear inhibition zones; therefore, they did not demonstrate antibacterial activity against P. aeruginosa, S. aureus, Enterococcus, and E. colispa
dc.description.sponsorshipUniversidad Libre Seccional Barranquilla -- Facultad de Ciencias Exactas y Naturales -- Maestría en Biotecnologíaspa
dc.formatPDFspa
dc.identifier.urihttps://hdl.handle.net/10901/26088
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dc.relation.referencesZhao, Y., Zhang, J., Wang, Q., Li, W., Li, J., Han, B., Wu, Z., Zhang, K., & Li, Z. (2010). Cylindrical-to-spherical shape transformation of lecithin reverse micelles induced by CO2. Langmuir, 26(7), 4581–4585. https://doi.org/10.1021/la904917nspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.subjectNanopartículasspa
dc.subjectSíntesis verdespa
dc.subjectMicela inversaspa
dc.subjectTamañospa
dc.subjectformaspa
dc.subjectActividad antimicrobianaspa
dc.subject.lembNanoparticulasspa
dc.subject.lembNanotecnologíaspa
dc.subject.lembAnnona Muricata L.spa
dc.subject.subjectenglishNanoparticlesspa
dc.subject.subjectenglishGreen synthesisspa
dc.subject.subjectenglishReverse micellespa
dc.subject.subjectenglishSizespa
dc.subject.subjectenglishShapespa
dc.subject.subjectenglishAntimicrobial activityspa
dc.titleEvaluación de la actividad antimicrobiana de nanopartículas de Hierro (FeNPs) sintetizadas con el extracto de Annona Muricata L. controladas mediante micela inversaspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.localTesis de Maestríaspa

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