Severe hepatic injury induced by carbamazepine associated with toxic epidermal necrolysis. Report of a case.

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dc.contributor.authorMarrugo B, Wilson R.
dc.contributor.authorOrtega Q, Rolando J.
dc.date2018-01-27
dc.descriptionToxic epidermal necrolysis and Stevens Johnson syndrome are rare and fatal disorders, characterized by severe skin and mucosal injury. These disorders are the same condition, it is differentiated by the degree of affection of the total body surface. The hypersensitivity reaction of drugs is the most frequent etiology of these two entities; On the other hand, the liver is also a target of lesions caused by medications, which can lead to severe hepatitis and even worse acute liver failure, leading to jaundice, encephalopathy and coagulopathy. The present case is a patient suffering a head trauma with the presence of subdural hematoma, days after the start of consumption of carbamazepine as anticonvulsant prophylaxis and acetaminophen for pain, generating skin lesion that compromised more than 30% of the body surface, injury severe hepatic disease with marked elevation of transaminases and encephalopathy, which could well correspond to subdural hematoma or hepatic damage; This generated great interest.en-US
dc.descriptionLa necrolisis epidérmica toxica y el síndrome de Stevens- johnson son trastornos raros y mortales, caracterizado por una lesión severa de la piel y mucosa. Estos trastornos son una misma condición, se diferencia por el grado de afección de la superficie corporal total. La reacción de hipersensibilidad de los fármacos es la etiología más frecuente de estas dos entidades; por otro lado, el hígado es también una diana de las lesiones causadas por medicamentos, pudiendo conducir hasta una hepatitis severa y hasta en peor de los casos falla hepática aguda, llevando a ictericia, encefalopatía y coagulopatia. El presente caso es un paciente que sufre un trauma craneoencefálico con presencia de hematoma subdural, días después inicia el consumo de carbamazepina como profilaxis anticonvulsivante y acetaminofén para el dolor, generando lesión en piel que comprometían más de un 30% de la superficie corporal, lesión hepática severa con elevación marcada de transaminasas y encefalopatía, que bien podría corresponder al hematoma subdural o a la lesión hepática; esto genero gran interés.es-ES
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dc.identifierhttps://revistas.unilibre.edu.co/index.php/biociencias/article/view/2245
dc.identifier10.18041/2390-0512/bioc..1.2245
dc.identifier.urihttp://hdl.handle.net/10901/14672
dc.languagespa
dc.language.isospaspa
dc.publisherUniversidad Librees-ES
dc.relationhttps://revistas.unilibre.edu.co/index.php/biociencias/article/view/2245/1713
dc.relation/*ref*/Hsu D, Brieva J, et al. Morbidity and Mortality of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Journal of Investigative Dermatology. 2016;136:1387-1397.
dc.relation/*ref*/Kohanim S, Palioura S, et al. Steven Johnson Síndrome/Toxic Epidermal Necrolisis – A Comprensive Review and Guide to Therapy. The Ocular Surface. 2016; 14:1
dc.relation/*ref*/Bastuji-Garin S, Berthold R, et al. Clinical Classification of Cases of Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome, and Erithema Multiforme. Archives of Dermatology. 1992;129
dc.relation/*ref*/Schwartz R, McDonough P, et al. Toxic Epidermal Necrolysis. American Academy of Dermatology. 2016;69:173
dc.relation/*ref*/Mockenhaupt M, Viboud C, et al. Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Assessment of Medication Risks with Emphasis on Recently Marketed Drugs. The EuroSCAR-Study. Journal of Investigative Dermatology. 2008;128:35-44
dc.relation/*ref*/Mukasa Y, Craven N. Management of Toxic Epidermal Necrolysis and Related Syndromes. Posgraduate Medical Journal. 2008;84:60-65
dc.relation/*ref*/Holt M, Ju C. Drug-induced liver injury. Handbook Experimental Pharmacology. 2010;196:3–27.
dc.relation/*ref*/Yuan L, Kaplowitz N. Mechanisms of Drug-Induced Liver Injury. Clinics in Liver Disease. 2013; 17:507-518
dc.relation/*ref*/Au J, Pockros P. Drug-Induced Liver Injury from Antiepileptic Drugs. Clinics in Liver Disease. 2013; 17:687-697.
dc.relation/*ref*/Bover T, Manns M. Acute liver failure. Zakim & Boyer`s Hepatology: A textbook of liver disease. 6ª Edition. Elsevier, 2012.
dc.relation/*ref*/Pirmohamed M, Leeder J. Anticonvulsivant Agents. Drug-Induced Liver Disease. 3° Edition. Elsevier, 2013.
dc.relation/*ref*/Stricker BHC. Drug-Induced Hepatic Injury. Amsterdam. Elsevier Science Publishers. 1992.
dc.relation/*ref*/Pellock JM. Carbamazepine Side Effects in Children and Adults. Epilepsia 1987; 28:S64-70.
dc.relation/*ref*/Ye Y, Yu-Hor B, Park H. Hypersensitivity Antiepileptic Drug. Immunology and Allergy Clinics of North America. 2014; 633-643.
dc.relation/*ref*/Bernal W, Wendon J. Acute Liver Failure. The New England Journal of Medicine. 2013;369:2525-34
dc.relation/*ref*/Bunchorntavakul C, Rajender K. Acetaminophen-related Hepatotoxity. Clinics in Liver Disease. 2013;17:587-607
dc.relation/*ref*/Cacoub P, Musette P, et al. The DRESS Syndrome: A Literature Review. The American Journal of Medicine. 2011;124:588-597
dc.relation/*ref*/Patrick P, James N. Clinical and Neurologic Manifestation of Minimal Hepatic Encephalopathy and Overt Hepatic Encephalopathy. Clinics in Liver Disease. 2015;19:461-472
dc.relation.ispartofjournalRevistas - Ciencias de la Saludspa
dc.rightsDerechos de autor 2018 Biocienciases-ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/deed.eses-ES
dc.rights.licenseAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.sourceBiociencias; Vol 13 No 1 (2018): Biociencias; 137-143en-US
dc.sourceBiociencias; Vol. 13 Núm. 1 (2018): Biociencias; 137-143es-ES
dc.source2390-0512
dc.source0124-0110
dc.subject.proposalNecrolisis epidérmica toxicaes-ES
dc.subject.proposalCarbamazepinaes-ES
dc.subject.proposalEncefalopatíaes-ES
dc.titleSevere hepatic injury induced by carbamazepine associated with toxic epidermal necrolysis. Report of a case.en-US
dc.titleLesión hepática severa inducida por carbamazepina asociado a necrolisis epidérmica tóxica. Reporte de un caso.es-ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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