Análisis en la investigación de los nutrientes neuroprotectores, en el paciente con enfermedad de Parkinson (EP).

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dc.contributor.advisorBuritica, Hector Mario
dc.contributor.authorVásquez Sánchez, María Paula
dc.contributor.authorTrujillo Tobón, Sarah
dc.coverage.spatialPereiraspa
dc.creator.emailsarahtrujillo454@gmail.comspa
dc.date.accessioned2024-12-04T17:12:50Z
dc.date.available2024-12-04T17:12:50Z
dc.date.created2024-11-29
dc.description.abstractLa enfermedad de Parkinson (EP), es uno de los trastornos neurodegenerativos más prevalentes a nivel mundial, afectando aproximadamente a 10 millones de personas. (1) La investigación sobre nutrientes neuroprotectores, ha emergido como un área prometedora para el desarrollo de intervenciones dietéticas, que podrían modificar el curso de la enfermedad. El objetivo de esta revisión fue, analizar los avances recientes en la investigación sobre nutrientes neuroprotectores en la enfermedad de Parkinson. Evaluando el potencial neuroprotectora como estrategias terapéuticas complementarias, se realizó una revisión bibliográfica siguiendo las directrices PRISMA (Preferred Reporting Items For Systematic Reviews and Meta-Analyses) consultando las bases de datos electrónicas PubMed, Scielo, Scopus, Dialnet, Science Direct y Google académico. Se incluyó estudios científicos, revisiones sistemáticas, ensayos clínicos aleatorizados y estudios de cohorte que evaluaran específicamente nutrientes con factor neuroprotector en la enfermedad de Parkinson. La vitamina E, el ácido docosahexaenoico (DHA), la coenzima Q10, los polifenoles y flavonoides demostraron modular vías inflamatorias y disminución de la α-sinucleina demostrando resultados prometedores; la evidencia actual sugiere un papel prometedor de los nutrientes neuroprotectores en la enfermedad de Parkinson, aunque se requiere mayor investigación para traducir estos hallazgos en intervenciones clínicas efectivas se destacan determinadas estrategias nutricionales personalizadas así como la intervención dietoterapéutica considerando factores genéticos, ambientales y el estadio de la enfermedad.spa
dc.description.abstractenglishParkinson's disease (PD), is one of the most prevalent degenerative disorders worldwide, affecting approximately 10 million people.(1) Research on neuroprotective nutrients has emerged as a promising area for the development of dietary interventions that could modify the course of the disease. Recent advances in research evaluating neuroprotective potential as complementary therapeutic strategies were analyzed, a literature review was conducted following PRISMA guidelines by consulting the electronic databases PubMed, Scielo, Scopus, Dialnet, Science Direct and Google Scholar. We included scientific studies, systematic reviews, randomized clinical trials and cohort studies that specifically evaluated nutrients with a neuroprotective factor in Parkinson's disease. Vitamin E, docosahexaenoic acid (DHA), coenzyme Q10, polyphenols and flavonoids were shown to modulate inflammatory pathways and decrease α-synuclein showing promising results; current evidence suggests a promising role of neuroprotective nutrients in Parkinson's disease, although further research is required to translate these findings into effective clinical interventions certain personalized nutritional strategies as well as dietary therapeutic intervention considering genetic, environmental and disease stage factors are highlighted.spa
dc.description.sponsorshipUniversidad Libre Seccional Pereira -- Facultad de Ciencias de la Salud, Exactas y Naturales -- Nutrición y Dietéticaspa
dc.formatPDFspa
dc.identifier.urihttps://hdl.handle.net/10901/30379
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/spa
dc.subjectEnfermedad de Parkinsonspa
dc.subjectNutrientesspa
dc.subjectNeuroprotectoresspa
dc.subjectAntiinflamatoriosspa
dc.subject.subjectenglishParkinson's diseasespa
dc.subject.subjectenglishNutrientsspa
dc.subject.subjectenglishNeuroprotectivespa
dc.subject.subjectenglishAnti-inflammatory Agentsspa
dc.titleAnálisis en la investigación de los nutrientes neuroprotectores, en el paciente con enfermedad de Parkinson (EP).spa
dc.title.alternativeAnalysis in the investigation of neuroprotective nutrients in the Parkinson's disease patientspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localTesis de Pregradospa

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