Efecto de dos dietas sobre la metilación global del ADN de adultos con obesidad

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dc.contributor.advisorMuñoz Pérez, Diana María
dc.contributor.authorMora Ramírez, Laura Daniela
dc.contributor.authorBetancourt López, María Victoria
dc.coverage.spatialPereiraspa
dc.creator.emailmariav-betancourtl@unilibre.edu.cospa
dc.creator.emaillaurad-morar@unilibre.edu.cospa
dc.date.accessioned2025-07-09T16:23:47Z
dc.date.available2025-07-09T16:23:47Z
dc.date.created2024-11-11
dc.description.abstractLa prevalencia de la obesidad y el sobrepeso se ha ido incrementando de manera sostenida en la mayoría de las poblaciones humanas. En Colombia una de cada dos personas tiene sobrepeso u obesidad. Esta patología puede tener causas epigenéticas en como la metilación del ADN, que puede ser modificada por la dieta. Objetivo: Comparar el efecto de dos dietas sobre la metilación global del ADN. Metodología: A través de un estudio cruzado se evaluaron los cambios en el % de metilación global del ADN de 44 adultos con obesidad, después de dos intervenciones dietéticas. Resultados: Se encontró un aumento del 31,25 % de metilación global del ADN con la dieta habitual en comparación con la dieta experimental, a la vez se evidencio un aumento de Vitamina C y E con esta última. Conclusión: La dieta experimental podría ser un factor protector ya que mantuvo el patrón global de metilación, sin embargo, se requieren más estudios que puedan evaluar la metilación de genes específicos.spa
dc.description.abstractenglishThe prevalence of obesity and overweight has been increasing steadily in most human populations. In Colombia, one in two people is overweight or obese. This pathology may have epigenetic causes such as DNA methylation, which can be modified by diet. Objective: Compare the effect of two diets on global DNA methylation. Methodology: Through a crossover study, changes in % global DNA methylation of 44 adults with obesity were evaluated after two dietary interventions. Results: An increase of 31.25% in global DNA methylation was found with the usual diet compared to the experimental diet, while an increase in Vitamin C and E was evident with the latter. Conclusion: The experimental diet could be a protective factor since it maintained the global methylation pattern, however, more studies are required that can evaluate the methylation of specific genes.spa
dc.description.sponsorshipUniversidad Libre Seccional Pereira -- Facultad de Ciencias de la Salud, Exactas y Naturales -- Nutrición y Dietéticaspa
dc.formatPDFspa
dc.identifier.urihttps://hdl.handle.net/10901/31463
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 2.5 Colombiaspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/spa
dc.subjectMetilaciónspa
dc.subjectADNspa
dc.subjectDietaspa
dc.subjectobesidadspa
dc.subject.subjectenglishMethylationspa
dc.subject.subjectenglishDNAspa
dc.subject.subjectenglishDietspa
dc.subject.subjectenglishobesityspa
dc.titleEfecto de dos dietas sobre la metilación global del ADN de adultos con obesidadspa
dc.title.alternativeEffect of two diets on global DNA methylation in adults with obesityspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localTesis de Pregradospa

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